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Postoperative radiation therapy is probably not necessary for fully resected CCS but may result in improved local control when negative margins cannot be achieved, a situation that frequently arises because complete surgical excision with wide margins at common locations is often not feasible without amputation

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3.7.4 Ferroptosis and kidney stones Kidney stones affect approximately 10% of the global population, with a 5-year recurrence rate as high as 50%, and are a risk factor for ESRD (274)

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